Journal of Movement Disorders

Brief communication

Effectiveness of Exercise on the Sequence Effect in Parkinson’s Disease: Suk Yun Kang, Young Ho Sohn; J Mov Disord. 2020;13(3):213-217. Published online August 31, 2020; DOI: https://doi.org/10.14802/jmd.20045

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Objective
To determine the benefits of motor training on the sequence effect (SE), an essential component of bradykinesia in Parkinson’s disease (PD).
Methods
Seven patients with de novo PD participated in this study. The patients performed regular pentagon drawing tests and exercises during four visits. The first two visits occurred before the start of medication, and the last two visits occurred at least six months after the start of medication. We assessed the severity of bradykinesia and SE at each visit and compared the results before and after exercise in both the de novo and treatment conditions.
Results
In the de novo condition, the severity of bradykinesia significantly improved after motor training (p = 0.018), but it did not resolve and only showed a trend of improvement after treatment (p = 0.068). The severity of the SE decreased significantly in the drug-naïve condition (p = 0.028) but not after medication (p = 0.273).
Conclusion
Our study suggests that regular motor training may be beneficial for the SE in PD.

Citations

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Exploring the Complex Phenotypes of Impaired Finger Dexterity in Mild-to-moderate Stage Parkinson’s Disease: A Time-Series Analysis
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Journal of Parkinson's Disease.2023; 13(6): 975. CrossRef
The Effects of Intensive Neurorehabilitation on Sequence Effect in Parkinson's Disease Patients With and Without Freezing of Gait
Alessia Putortì, Michele Corrado, Micol Avenali, Daniele Martinelli, Marta Allena, Silvano Cristina, Valentina Grillo, Luca Martinis, Stefano Tamburin, Mariano Serrao, Antonio Pisani, Cristina Tassorelli, Roberto De Icco
Frontiers in Neurology.2021;[Epub] CrossRef

Original Articles

Analysis of the Substantia Innominata Volume in Patients with Parkinson’s Disease with Dementia, Dementia with Lewy Bodies, and Alzheimer’s Disease: Hee Jin Kim, Ji Eun Lee, Soo Jeong Shin, Young Ho Sohn, Phil Hyu Lee; J Mov Disord. 2011;4(2):68-72.; DOI: https://doi.org/10.14802/jmd.11014

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Abstract PDF

Background and Purpose

The substantia innominata (SI) contains the nucleus basalis of Meynert, which is the major source of cholinergic input to the cerebral cortex. We hypothesized that degeneration of the SI and its relationship to general cognitive performance differs in amyloidopathy and synucleinopathy.

Methods

We used magnetic resonance imaging (MRI)-based volumetric analysis to evaluate the SI volume in patients with amnestic mild cognitive impairment (aMCI), Alzheimer’s disease (AD), Parkinson’s disease-mild cognitive impairment (PD-MCI), PD with dementia (PDD), dementia with Lewy bodies (DLB), and healthy elderly controls. The correlation between SI volume and general cognitive performance, measured using the Korean version of the Mini-Mental State Examination (K-MMSE), was examined.

Results

Compared to control subjects, the mean normalized SI volume was significantly decreased in all of the other groups. The normalized SI volume did not differ between the subjects with PDD and DLB, whereas it was significantly smaller in subjects with PDD (p = 0.029) and DLB (p = 0.011) compared with AD. In subjects with PD-related cognitive impairment (PD-MCI, PDD, or DLB), there was a significant positive correlation between the SI volume and K-MMSE score (r = 0.366, p < 0.001), whereas no correlation was seen in subjects with AD-related cognitive impairment (aMCI or AD).

Conclusions

Our data suggest that the SI loss is greater in synucleinopathy-related dementia (PDD or DLB) than in AD and that the contribution of the SI to cognitive performance is greater in synucleinopathy than in amyloidopathy.

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Deep Learning Segmentation of the Nucleus Basalis of Meynert on 3T MRI
D.J. Doss, G.W. Johnson, S. Narasimhan, J.S. Shless, J.W. Jiang, H.F.J. González, D.L. Paulo, A. Lucas, K.A. Davis, C. Chang, V.L. Morgan, C. Constantinidis, B.M. Dawant, D.J. Englot
American Journal of Neuroradiology.2023; 44(9): 1020. CrossRef
Manual and automated analysis of atrophy patterns in dementia with Lewy bodies on MRI
Eya Khadhraoui, Sebastian Johannes Müller, Niels Hansen, Christian Heiner Riedel, Philip Langer, Charles Timäeus, Jens Wiltfang, Caroline Bouter, Claudia Lange, Marielle Ernst
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Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer’s disease
Julia Schumacher, Nicola J Ray, Calum A Hamilton, Paul C Donaghy, Michael Firbank, Gemma Roberts, Louise Allan, Rory Durcan, Nicola Barnett, John T O’Brien, John-Paul Taylor, Alan J Thomas
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Metric magnetic resonance imaging analysis reveals pronounced substantia-innominata atrophy in dementia with Lewy bodies with a psychiatric onset
Niels Hansen, Sebastian Johannes Müller, Eya Khadhraoui, Christian Heiner Riedel, Philip Langer, Jens Wiltfang, Charles-Arnold Timäus, Caroline Bouter, Marielle Ernst, Claudia Lange
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In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Ruth A. Cromarty, Paul C. Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T. O'Brien, Alan J. Thomas
NeuroImage: Clinical.2021; 30: 102604. CrossRef
EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease
Julia Schumacher, Alan J. Thomas, Luis R. Peraza, Michael Firbank, Ruth Cromarty, Calum A. Hamilton, Paul C. Donaghy, John T. O’Brien, John-Paul Taylor
Alzheimer's Research & Therapy.2020;[Epub] CrossRef
Transcriptional network analysis in frontal cortex in Lewy body diseases with focus on dementia with Lewy bodies
Gabriel Santpere, Paula Garcia‐Esparcia, Pol Andres‐Benito, Belen Lorente‐Galdos, Arcadi Navarro, Isidro Ferrer
Brain Pathology.2018; 28(3): 315. CrossRef
Nucleus Basalis of Meynert Stimulation for Dementia: Theoretical and Technical Considerations
Deepak Kumbhare, Viktoras Palys, Jamie Toms, Chathurika S. Wickramasinghe, Kasun Amarasinghe, Milos Manic, Evan Hughes, Kathryn L. Holloway
Frontiers in Neuroscience.2018;[Epub] CrossRef
Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms
Paula Garcia-Esparcia, Irene López-González, Oriol Grau-Rivera, María Francisca García-Garrido, Anusha Konetti, Franc Llorens, Saima Zafar, Margarita Carmona, José Antonio del Rio, Inga Zerr, Ellen Gelpi, Isidro Ferrer
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Meynert’s Nucleus Complex White Matter Abnormalities in Autism Spectrum Disorders: An MRI Study
Matteo Pardini, Francesco G. Garaci, Laszlo Zaborszky, Filadelfo Coniglione, Gianluca Serafini, Martina Siracusano, Francesca Benassi, Leonardo Emberti Gialloreti
Journal of Intellectual Disability - Diagnosis and Treatment.2017; 4(4): 185. CrossRef
Biomarkers for dementia and mild cognitive impairment in Parkinson's disease
Manuel Delgado‐Alvarado, Belén Gago, Irene Navalpotro‐Gomez, Haritz Jiménez‐Urbieta, María C. Rodriguez‐Oroz
Movement Disorders.2016; 31(6): 861. CrossRef
Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease
Alan King Lun Liu, Raymond Chuen-Chung Chang, Ronald K. B. Pearce, Steve M. Gentleman
Acta Neuropathologica.2015; 129(4): 527. CrossRef

Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type: Hyun J. Hong, Sook Keun. Song, Phil Hyu Lee, Young Ho Sohn, Ji E. Lee; J Mov Disord. 2011;4(1):41-45.; DOI: https://doi.org/10.14802/jmd.11007

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Abstract PDF

Background and Purpose

We investigated the cognitive profiles in a large sample of patients with multiple system atrophy-cerebellar ataxia (MSA-C) and compared directly them in patients with clinical diagnosis of probable MSA-C without dementia and control subjects with intact cognition.

Methods

We prospectively enrolled 26 patients with clinical diagnosis of probable MSA-C. All patients underwent a standardized neuropsychological test of the Seoul Neuropsychological Screening Battery.

Results

The score of Korean version of the Mini- Mental State Examination was significantly lower in patients with MSA-C (27.2 ± 2.5) than in control subjects (28.9 ± 1.0, p = 0.003). Patients with MSA-C showed a significantly worse performance in visuospatial function, 3 words recall, verbal immediate, delayed and recognition memory, visual delayed memory, phonemic and sementic Controlled Oral Word Association Test, and ideomotor praxis (p < 0.05).

Conclusions

Patients with MSA-C show more severe and more widespread cognitive dysfunctions than controls. Our results also indicate that cognitive dysfunction in patients with MCA-C is suggestive of disruption of the cerebellocortical circuits.

Citations

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Simona Raimo, Mariachiara Gaita, Maria Cropano, Giusi Mautone, Alfonsina D’Iorio, Luigi Trojano, Gabriella Santangelo
Neuropsychology Review.2023; 33(2): 514. CrossRef
Morphological differences between the two major subtypes of multiple system atrophy with cognitive impairment
Kurt A. Jellinger
Parkinsonism & Related Disorders.2023; 107: 105273. CrossRef
Mild cognitive impairment in multiple system atrophy: a brain network disorder
Kurt A. Jellinger
Journal of Neural Transmission.2023; 130(10): 1231. CrossRef
Cognition in Patients With Multiple System Atrophy (MSA) and Its Neuroimaging Correlation: A Prospective Case-Control Study
Santosh Dash, Rohan Mahale, M. Netravathi, Nitish L Kamble, Vikram Holla, Ravi Yadav, Pramod K Pal
Cureus.2022;[Epub] CrossRef
Cognition in multiple system atrophy: a single‐center cohort study
Sabine Eschlböck, Margarete Delazer, Florian Krismer, Thomas Bodner, Alessandra Fanciulli, Beatrice Heim, Antonio Heras Garvin, Christine Kaindlstorfer, Elfriede Karner, Katherina Mair, Christoph Rabensteiner, Cecilia Raccagni, Klaus Seppi, Werner Poewe,
Annals of Clinical and Translational Neurology.2020; 7(2): 219. CrossRef
Neuropathological findings in multiple system atrophy with cognitive impairment
Kurt A. Jellinger
Journal of Neural Transmission.2020; 127(7): 1031. CrossRef
An update on MSA: premotor and non-motor features open a window of opportunities for early diagnosis and intervention
Viorica Chelban, Daniela Catereniuc, Daniela Aftene, Alexandru Gasnas, Ekawat Vichayanrat, Valeria Iodice, Stanislav Groppa, Henry Houlden
Journal of Neurology.2020; 267(9): 2754. CrossRef
A case of multiple system atrophy
Jing Guo, Fuying Liu, Tingting Liu, Xin Zhang, Yong Luo
Journal of International Medical Research.2019; 47(11): 5839. CrossRef
Cognitive impairment before changes appear on [18F]‐fluoro‐D‐glucose positron emission tomography images in a patient with possible early‐stage cerebellar‐predominant multiple system atrophy
Masahiko Takaya, Masahiko Atsumi, Tomoyuki Hirose, Kazunari Ishii, Osamu Shirakawa
Psychogeriatrics.2016; 16(3): 216. CrossRef
Fragile X-associated tremor/ataxia syndrome: phenotypic comparisons with other movement disorders
Erin E. Robertson, Deborah A. Hall, Andrew R. McAsey, Joan A. O’Keefe
The Clinical Neuropsychologist.2016; 30(6): 849. CrossRef
A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy
Brian Spencer, Elvira Valera, Edward Rockenstein, Margarita Trejo-Morales, Anthony Adame, Eliezer Masliah
Molecular Neurodegeneration.2015;[Epub] CrossRef
Cognitive Impairment and Its Structural Correlates in the Parkinsonian Subtype of Multiple System Atrophy
Ji Sun Kim, Jin-ju Yang, Dong-Kyun Lee, Jong-min Lee, Jinyoung Youn, Jin Whan Cho
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Case Report

Restlessness with Manic Episodes due to Right Parietal Infarction: Suk Yun Kang, Jong Won Paik, Young Ho Sohn; J Mov Disord. 2010;3(1):22-24.; DOI: https://doi.org/10.14802/jmd.10007

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Abstract PDF

Mood disorders following acute stroke are relatively common. However, restlessness with manic episodes has rarely been reported. Lesions responsible for post-stroke mania can be located in the thalamus, caudate nucleus, and temporal and frontal lobes. We present a patient who exhibited restlessness with manic episodes after an acute infarction in the right parietal lobe, and summarize the case reports involving post-stroke mania. The right parietal stroke causing mania in our case is a novel observation that may help us to understand the mechanisms underlying restlessness with mania following acute stroke.

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Restlessness with manic episodes induced by right-sided multiple strokes after COVID-19 infection: A case report
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Post stroke delirium
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Original Articles

Hyperhomocysteinemia in Patients with Parkinson’s Disease and Relationship to Vitamin B Level: Hae-Won Shin, Young Ho Sohn; J Mov Disord. 2009;2(1):33-36.; DOI: https://doi.org/10.14802/jmd.09008

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Abstract PDF

Background:

Plasma homocysteine (Hcy) levels are increased in patients with Parkinson’s disease (PD) undergoing levodopa treatment. We measured the Hcy levels in PD patients and assessed the relationship between Hcy level and features of PD, cognitive function and vitamin B status.

Methods:

Concentrations of Hcy, vitamin B₁₂ and folate were measured in 33 PD patients and 41 normal control individuals. Mini-mental Status Examination (MMSE) was assessed in all subjects. In PD patients, Hoehn & Yahr stage and Unified Parkinson Disease Rating Scale (UPDRS) motor scores were also examined.

Results:

Plasma Hcy levels were lower in PD patients than in control individuals. Hcy level was inversely correlated with vitamin B₁₂ and folate levels in the PD group but not in control individuals. Age, symptom duration, UPDRS motor scores, MMSE score, levodopa dose and duration of treatment did not differ between patients with Hcy >14 μmol/L and those with Hcy <14 μmol/L.

Conclusions:

Plasma Hcy levels were increased in PD patients with levodopa treatment and were related to vitamin B level. These results indicate that vitamin supplementation may be beneficial in levodopa-treated PD patients, although hyperhomocysteinemia did not affect the motor and cognitive status of PD patients.

Citations

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An umbrella review of systematic reviews with meta-analysis on the role of vitamins in Parkinson’s disease
Sama Rahnemayan, Sasan Ghazanfar Ahari, Reza Rikhtegar, Sevda Riyahifar, Sarvin Sanaie
Acta Neurologica Belgica.2023; 123(1): 69. CrossRef
Association between the risk and severity of Parkinson’s disease and plasma homocysteine, vitamin B12 and folate levels: a systematic review and meta-analysis
Yuxin Quan, Jisen Xu, Qing Xu, Zhiqing Guo, Ruwei Ou, Huifang Shang, Qianqian Wei
Frontiers in Aging Neuroscience.2023;[Epub] CrossRef
Large-Fiber Neuropathy in Parkinson’s Disease: Clinical, Biological, and Electroneurographic Assessment of a Romanian Cohort
Oana Maria Vanta, Nicoleta Tohanean, Sebastian Pintea, Lacramioara Perju-Dumbrava
Journal of Clinical Medicine.2019; 8(10): 1533. CrossRef
Parkinson's disease, hyperhomocysteinemia and thrombosis: A dangerous combination
S. Bellakhal, E. Gharbi, Z. Meddeb, M. Mrouki, I. Abdelkéfi, M.-H. Douggui
Revue Neurologique.2016; 172(6-7): 398. CrossRef
Associations between B Vitamins and Parkinson’s Disease
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Unilateral Standing Leg Tremor as the Initial Manifestation of Parkinson Disease: Suk Yun Kang, Sook-Keun Song, Jin-Soo Kim, Young Ho Sohn; J Mov Disord. 2009;2(1):29-32.; DOI: https://doi.org/10.14802/jmd.09007

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Abstract PDF

Background:

The aim of this study was to analyze the different forms of leg tremors exhibited while standing in patients with Parkinson disease (PD), and to determine if the type of leg tremor exhibited is indicative of prognosis or treatment response in PD patients.

Methods:

We studied the clinical characteristics of five PD patients (all women; mean age, 59 years, range, 53–64 years) with unilateral standing leg tremor as the initial manifestation of PD, including their electrophysiological findings and the results of long-term follow-up.

Results:

For each patient, parkinsonism either existed at the time of onset of the initial symptoms or developed later. Patient responses to drugs were generally good, but one patient showed a poor response to drugs, even though she had only a low frequency leg tremor. For two patients whom we could observe during the 10-year follow-up period, neither the leg tremor nor parkinsonism was aggravated.

Conclusions:

There are two forms of unilateral standing leg tremor in PD. One form is high frequency, similar to the primary orthostatic tremor. The other is low frequency and similar to the parkinsonian resting tremor. Based on these observations, it appears that progression might be slow if PD patients have standing leg tremor as the initial manifestation.

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Orthostatic tremor as initial presentation of Parkinson’s disease
Y R Chiew
QJM: An International Journal of Medicine.2023; 116(7): 549. CrossRef
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